Get a verbose log from lr-picodrie - see here how to enable it during startup - and post the log file contents on pastebin.com.

@saccublenda Ive found switching between discs was an issue when select-x to retroarch menu When using bin. and .cue roms. Try using just .iso roms for mutli disk games like night trap and ground zero texas. Worked for me

If it also happens on Kega Fusion, it's going to happen on real hardware.

If it's excluve to PicoDrive, try updating the core because there has been some major improvement in 32X emulation (exclusive to the core, not the base code).

Else, you'll have to live with it because there's no other portable open source 32X emulator (until it gets fixed).

@titchgamer Good to hear you were able to solve.
Yes, sometimes things can really get messed up.
Backup is your friend ;-)

@brad2600 im not sure if it is playable. I havent found a working rom either.

@edmaul69 I apologize. I should've made clear the platform I was referring to in my first post. I've edited the post to reflect that.