@mortalwombat said in Any SegaCD/Turbografx-16 fans here? Recommendations welcome:

Never really played the PSP and am a bit skeptical to do so if the Pi already has trouble/can't play the PS2

A pi 4 handles many psp games surprisingly well. Even more performance can be gained by overclocking and setting the display resolution to 720p instead of 1080p via the runcommand menu. Some games will require a little frameskipping and others will be fine without it.

A Sega CD game? That would probably instantly explain why it isn't working. I knew I found it in a pile of other TG-16 roms so that's why I stuck it there but if it belongs in the Sega CD pile then I'll give that a whirl.

I'll keep picking at this one rom and emulator at a time.

you can check the following thread (or just the first post, OP summarised it nicely)
https://retropie.org.uk/forum/topic/7934/ignition-dosbox-working

similar approach can also be used to have a well organised DOS games in RetroPie gui

Metal jesses on youtube received the test unit. There using a piorange. IDK if it's better or worse then the raspberry pi but they figured out to play games off the disk. Check it out on youtube for yourself.