@eberhab After more research it turns out that this is a "Pro Controller" related issue which affects all cores and emulators. It has already been beautifully solved here: https://retropie.org.uk/forum/topic/16503/how-to-connect-a-switch-pro-controller-with-analog-stick-without-xboxdrv

@codafire

Hi. You kinda skipped a few steps in describing the issue. What emulator are you using. What version of Retropie? RetroArch? There are 4 emulator options for Dos and each is slightly different version from each other. So that's really important.

Also... Are you saving the config to the same file or renaming it to a new one? How are you doing this in the emulator? Do you know how to look at the files of RetroPie? If so, what does the .map file say?

@mitu Thank you so much! Indeed, it was precisely in the full path to the CDROM folder.

As a result, the command looks like this:

[autoexec] MOUNT c /home/pi/RetroPie/roms/pc-games c: cd Rayman MOUNT d /home/pi/RetroPie/roms/pc-games/Rayman/cdrom -t cdrom RAYMAN.EXE EXIT