OK so this worked:

I added the following to runcommand-onlaunch.sh

rm /opt/retropie/configs/ps2/Config/cache/vulkan_pipelines.bin && rm /opt/retropie/configs/ps2/Config/cache/vulkan_shaders.bin && rm /opt/retropie/configs/ps2/Config/cache/vulkan_shaders.idx

It did not appear to like them on separate lines. Now when a game launches, it deletes those three files, and if I'm loading a PS2 game with AetherSX2 it re-creates them once the game loads, but then deletes them before the next game.

So this way those files never get bloated and not hog down any other games.

@derebo RetroPie logs every installation in $HOME/RetroPie-Setup/logs, can you look into the last log file to see if the xboxdrv installation was successful ? You can also re-run the installation to generate a new log file and then post the log file on pastebin.com.

Much obliged, thanks

This FoFix is very interesting. I might not ever get 'The Monkeys: Rock Band', but this could be the next best thing.