Finally i get rid of save/load state functionality. i change the following:

1- This is for the gamepad.

i remove the lines for save/load states.

2- This is for the keybord.

From /opt/retropie/configs/all/retroarch.cfg
i change the lines from

# input_save_state = f2
# input_load_state = f4
input_save_state = f22
input_load_state = f44

3- This is to hide save/load state option, in rgui quick menu.

i add to the/opt/retropie/configs/all/retroarch.cfg

the line quick_menu_show_save_load_state = "false"