Exagear which i didnt get a chance to try i believe runs off some custom WINE variants used for the project. Dont quote me on any of that.

For older games though including my main RetroPie install im using a x86 PC running Kubuntu at the moment, but specifically i use playonlinux within this.
I had absolutely no troubles creating a WINE container using this program to play some older games i have such as Gothic 1, 2, 3 (my personal favorites) as well as i even got warbirds running which i recall playing on w95 back in the day. Neverwinter nights 1 and 2 are also setup and had almost zero troubleshooting involved though i only played 1 briefly..Great game btw!

You said you're running windows so WINE isn't an option, but something to consider as maybe even a dual boot. You also don't need ZOMG hardware to get these older games running even if you did at the time such as integrated intel works well so does older Nvidia cards.

Also Neverwinter Nights is coming to the xbox one and i think PS4 here shortly...Im not sure how it will play with a controller, but its day one purchase easy for me! The Titan quest port worked pretty well with a controller so im optimistic.

@herb_fargus While it is not quite as simple as they advertise (and they do a LOT of advertising...) it does eventually work just by turning it on and then running your WIndows app. I'd say it is worth the money.