@JimmyFromTheBay said in Does Megumi Rescue (Sega Master System) work on anything?:

FBNeo-SMS gets closest - the game starts but the controls are totally wonky. Right and left are back to front and you can't move into the left-hand half of the screen.

The arcade version works properly in FBNeo, i don't know about the sms version (probably nobody tried it), i'll try to take a look soon.