@nyvram from the distance: If your room audio has some API reachable from the RetroPie you may consider the scripting function for specific events (since ES v2.9.2). https://retropie.org.uk/docs/EmulationStation/#scripting

The event game-start passes two parameters to every script in the folder ~/.emulationstations/srcipts/game-start/: ROM and basename (easiest is to echo them in a test script to determine what they represent exactly.)

Or put your actions for the room audio in runcommand-onstart/-onend.

HTH