@parabolic said in Pi Zero dedicated 1 game mame. Is there a optimized build for this?:

but its well emulated in MAME

That'll entirely depend on what you mean by "well" and the MAME version you are using. Using a pi zero might impede your choice about that. For the reminder, older MAME versions will be less likely to be accurate (i.e. faithful to the original game), and the newer versions usually require better machines.