@George-Spiggott There should be, yes. Although I think (I may well be wrong) only Angrylion via Parallel N64 is the only vulkan N64 video plugin, redream and ppsspp should be fine using vulkan.

There will also likely be some performance gain for using KMS over the current 'fake' KMS once those issues have been ironed out and would happen before Vulkan (if it ever happens!).

There some games that doesn't work with the ir-pcsx-rearmed core. I think Psybadek is one of them.
I was test it in a Pi 3 and it crash too.

I couldn’t find anything in Retropie 4.6 beta.

From the 4.6 announcement:

RetroArch updated to v1.8.5.

Support for real CD ROM, with the ability to dump the disc image.

I found a YouTube video using Retroarch but it mentions a download folder which I don’t have.

Try looking in \\retropie\configs\all\retroarch\downloads

I also have no cores in Retroarch with which to play the disc.

What disc did you rip ?