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@h3r3tic I just tested Streets of Rage 2 with lr-picodrive over LAN and played until the 2nd stage and it ran very smoothly. No sync issues or little half second pauses. Much better experience than lr-snes9x2010!
Every game that has 2+ player mode can be played online. You should read this Wiki page:
https://github.com/retropie/retropie-setup/wiki/netplay