@mswer Maybe the ROM file is corrupted. Re-copy the ROM back to the ROM folder and retry.
I use the lr-genesis-plus-gx emulator and I have no problems. with the lr-picodrive emulator it does not work
@pikgoggle while in the game you need to go into the retroarch gui. In quick menu, options i believe it is, you need to set all regions to output pal or ntsc or whatever region you use.