Okay, so now I'm getting blanking AND random "No Signal" to the TV. The no signal issue recovers when I exit the game. Could it be my seven dollar HDMI cable?

Disabling overscan and setting my display to 1:1 seems to have fixed the issue. Not sure what changed as I was using the same settings all this time and it suddenly had issue playing the videos.

Thanks guys

@viking.hellfire CD to /RetroPie-Setup then run the script with "sudo ./retropie_setup.sh" that should fix your issue getting retropie setup to work cheer