For screen and mouse/analog rotate (book mode), see here for a workaround:
It relies on lr-desmume2015. It is a workaround as the book mode issue is neither implemented yet in the lr-desmume2015 nor in retroarch.
@Gokilz would you mind adding the rotate/book mode aspect to the subject on your initial post? This would make it easier to find this topic in future when searching for a similar issue as yours.