Honestly, I can't really see something like this becoming successful. The Atari 2600 has the AtariAge crowd that loves developing homebrews and putting them on carts, but I personally don't see this happening with the NES. Not that it can't happen, but I think that the motivating force that drives their homebrew community isn't really there in the NES communities.
The 8-bit era was when a lot of iconic franchises like Mario, Castlevania, Final Fantasy, and Megaman came of age, and much of our love for the NES is tied strongly to our memories of those games. If you take a look at some of the 8-bit indie games out there like Shovel Knight, a lot them play the nostalgia card and are meant to remind us of those franchises.
The Atari 2600 was more about the games and not so much on characters (even Pitfall Harry is rather generic), so the focus becomes more on what you can do with limited sound/graphics and a one-button joystick. Unfortunately, that way of thinking doesn't work for the NES because it raised the bar for gaming as whole, and gave rise to memorable characters that we are now attached to. I can look past the fact that Wall Jump Ninja features a generic ninja and wonder what the gameplay is like, but my first reaction with Eskimo Bob is, why should I be interested?
