Sorry, I have messed up my forum notification settings, but they should be good again now 🤦‍♂️
Sort for this delayed reply!

The ControlBlock driver was updated five months ago for some RPi 5 specifics, but if a new kernel version introduces changes to the device tree, the driver probably needs an update again. I will take a look at this! I will update the test script that comes with driver as well. It is not up to date anymore and not very helpful with the RPi 5.

@retropieuser555

Using this product: https://www.amazon.com/dp/B0CRK4YB4C?psc=1&ref=ppx_yo2ov_dt_b_product_details

Uses the PCIe Ribbon connection available on the Pi5 and some of the pins from the I/O header.

@t01mkr said in Setting up an nvme as rom storage...:

. I was wondering if it's possible to use symbolic links instead. Does anyone know?

Yes, but why ? You're already mounting your disc, why not use the right folder for it in the first place.

@truglodite said in How can I boot RetroPie from NVMe or SSD (without SD)?:

I am guessing retropie still will write heavily to the sd card despite roms being on an external, correct? Not sure if sd wear is a big deal with retropie, so figured I'd ask if it was and if there's a similar way to mitigate.

Not really, gaming is not a write-heavy process. Game saves and save states are written to the ROM's folder by default and unpacking .zip ROMs is usually done in RAM.
There is no constant write load using RetroPie, like a monitoring/data collection/aggregation process entails, so a good sdcard and proper power source is usually enough.