@sirhenrythe5th Mine went crazy when using the well known Tab-Menu to set the MAME input. First controller was fine, the other 3 not so great. Once I got one straight I updated the config file to quickly setup the rest. I have it all pre-configured now so if I had to do it again its just a copy-past of the config file. Should save anyone else time.
Please do not post a support request without first reading and following the advice in https://retropie.org.uk/forum/topic/3/read-this-first