Add me to that too. Just wanted to say thanks to Loganmc10 for the absolutely amazing work done on N64 for the Pi! I'm still on 4.0.2 and that is fantastic, so to hear it's even better with the latest update is just incredible.
I noticed the same thing this morning during my play for the MAME ROW. I just updated to RetroPie 4.1.1 (2ceeb8a) to try to fix it. This definitely seems like a regression. I used to be able to press Select+X to get out of RGUI and get back into the game. I know it's not RetroPie's doing. It's also been reported over on GitHub thanks to dankcushions.