I'm not aware of any issues with 22.04. There may have been, at the time it was launched, 2 years ago, but there shouldn't be today. Again, 18.04 is not supported upstream and support for it from various emulators is dwindling.

@wec777 Try running sudo apt update && sudo apt upgrade before installing RetroPie again. Your problem looks similar to this issue, which seems to be a timing issue in the update list.
RetroPie doesn't install any repositories, it uses the ones provided by your Linux distribution.

I don't think so - if your desktop is runing and EmulationStation is also running, then the GPU is clearly supported. Ubuntu 21.10 is quite a recent distribution and the Iris Pro 580 (Skylage generation) is from 2015.

Hmmm. Yes, that's a good point. Well I cant understand why I did the very same steps on both NUCs yet no blank screens on my Gen4. Anyway, its not an issue as I'm not using the Skylake anymore.

Anyway. here is the output from a default core, not sure if it can help you decide what the difference is but Im dropping it here for your review if you have time:
https://pastebin.com/rCm2NDf2

Well, It turns out that my sound problem was probably due to the display refresh rate not being on sync.

After many reinstalls (both OS and Retropie) I was able to make sense of all this and I now can enjoy Retropie again on my old laptop with Lubuntu 20.04.

Thank you mitu for your time, this is really appreciated.

I think @quicksilver might be right. On the PC, the actual start-up is done via $HOME/.config/autostart/retropie.desktop. Modify it and add a delay before emulationstation starts

[Desktop Entry] Type=Application Exec=gnome-terminal --full-screen --hide-menubar -e "sleep 5 && emulationstation" Hidden=false NoDisplay=false X-GNOME-Autostart-enabled=true Name[de_DE]=RetroPie Name=rpie Comment[de_DE]=RetroPie Comment=retropie Icon=/usr/local/share/icons/retropie.svg Categories=Game

@mitu Thanks will do!

@mitu
After reinstalling everything seems to work fine. Will test for a few days now. Thanks for the assistance.

@geekomaniac Looks like an upstream bug. I suppose you don't have a x86_64 cross-compiler installed ?

Actually, your mileage may vary by doing this when it comes to the emulators because although they all compiled, some of them crashed when executed.

Much better to use the latest 16.04 LTS or later on a PC with a CPU with core2duo or later.

Please update retropie-setup and try again.