@mediamogul Yeah, I have to wonder if something in a kernel update caused things to get funky.
For what it's worth, while adding this week's MAME ROW games to my system I updated to 4.3.15 (07d9f95) and it didn't resolve the issue. I'm hoping either reverting to a really old version of RetroPie and then just not doing any updates, ever, or updating to the new Stretch version will resolve the problem. I haven't made the time yet to disassemble everything and put a different card in to try that route.