Thank you for all the help, everyone. I managed to compress my entire collection into CHD files. Much cleaner, and much smaller space-wise. And, they all work...except for the Sega-CD 32x games (there's only three or four of those). I guess I have to do some more homework on that one.
Not all my images were bin/cue. Getting them to be bin/cue so I could convert them to CHD was tedious and sometimes frustrating, but I got it done.
Thanks again.