@Thorr69 thanks for the reply; i didn't know about that setting and thank you for sharing, but that's not what's going on in this case. some games for the msx just have the buttons swapped from what you'd expect, like Vampire Killer, as mentioned in the video linked below.
i have a few solutions for swapping a and b now for this emulator, but now i'm focused on mapping keyboard keys to buttons in lr-bluemsx (or adjusting the emulation speed in lr-fmsx), which i'm still hoping to figure out.
this video mentions that the buttons are swapped from what you'd expect in Vampire Killer even if you're playing on an actual msx with a controller (mentioned at timestamp 4:35, which i tried to include in the link):