@willelind said in GPIOnext input works great during menu but stops working after game boots:
What did you mean by that? It seems that my input keybindings are from the /opt/retropie/configs/all/retroarch.cfg file, listed under keyboard, not joypad/gamepad.
Look in a verbose log and see if an additional joystick/gamepad input type is detected. It may be that GPIONext adds an additional gamepad device, even if you configure it as a keyboard.