I uncommented it and set the rights as you advised:
pi@raspberrypi:~ $ cat /etc/rc.local
#!/bin/sh -e # # rc.local # # This script is executed at the end of each multiuser runlevel. # Make sure that the script will "exit 0" on success or any other # value on error. # # In order to enable or disable this script just change the execution # bits. # # By default this script does nothing. #hciconfig hci0 up #hciconfig hci0 pscan "/opt/retropie/supplementary/retropie-manager/rpmanager.sh" --start --user pi 2>&1 > /dev/shm/rpmanager.log & exit 0 Result: pi@raspberrypi:~ $ /opt/retropie/supplementary/retropie-manager/rpmanager.sh --isrunning RetroPie-Manager is not running Sad.....